Synthesis, Characterization and Biological Activity of Fe-iii and Co-ii Complexes Derived from 4-chloro-2-[(2-furanylmethyl)-amino]-5 Sulfamoylbenzoic Acid

The present investigation is an attempt to synthesize and characterize the ligand 4-chloro-2-[(2furanylmethyl) amino]-5-sulfamoylbenzoic acid, and its Fe-III and Co-II complexes. The nature of bonding and the geometry of the complexes have been deduced from elemental analysis, magnetic moment measurements and conductivity measurements. Conductometric titrations have suggested metal-ligand ratio of 1:2 for both Fe(III) and Co(II) complexes. The ligand behaves as a bidentate with N, O donor atoms. The electronic absorption spectra and magnetic susceptibility measurements of the complexes indicates octahedral geometry for both the complexes. IR, UV-Visible and SEM studies have been carried out to suggest the tentative structure for the complexes. The synthesized ligand as well as their metal complexes were screened for diuretic activity. The results revealed that the complexes are more potent diuretic than the ligand.